The convention is that 32-bit programs live in Program Files (x86), and 64-bit program files live in Program Files.
I have 2 active hard drives on my production DAW, and the primary drive (C:) has the OS, application programs, program data and appdata. All sample libraries, projects, and audio data live on the second drive.
I have an additional internal drive that I use for periodic cloning of the C: drive, and I have 2 external drives that house backups - one is kept onsite and the other offsite.
Lots of choices for where you put things, I hope the above gets you thinking about what works for you.
Bob Bone