All - I would just like to add that I'm also experiencing cracks and pops, where I had experienced none previously. Everything is USB for me. I'm experiencing it even on files that are brand new files with just one audio track and nothing else. I've compensated by backing off on the latency. However, I used to be able to have super fast latency settings.
I am wondering if a couple of us could reproduce it down to the most basic circumstances for each of us, like I've reduced it to a brand new file with only one audio track. What other variables might be contributing, etc. I can't speak to the firewire folks, but USB audio interfaces have been rock solid for me with no clicks or pops until recently, like I mean the last patch.