Yup - this issue comes up quite frequently.
Anderton's notion to hit 'E' is really quick at letting you know if one or more effects are causing your latency issues, and hitting 'E' again will turn the effects back on.
So, please try the above and post back, and please also post back with the following info:
Audio interface: Sample Rate and ASIO Buffer Size
Sonar: Driver Mode, Sample Rate, Total Roundtrip Latency, Record Bit-Depth
Thanks,
Bob Bone