CakeAlexSThis appears more a motherboard compatibility with the firewire card than a Focusrite compatibility with the firewire card I assume? If you can't get the firewire card working there's no chance in hell you are going to get the saffire working. Here are firmware updates and chipset drivers, latest firmware was released 3 weeks ago:http://www.asus.com/Motherboards/Z87PRO/#support After this please check in with Intel autoupdate:http://www.intel.com/p/en_US/support/detect Then try different slots... What is the exact model of the SIIG firewire card?