I did have auto-save enabled but somehow this time the auto-save also failed. There was some message I think indicating that because recording was in progress when it crashed, it couldn't open. Then there was some other recovery option, but it gave me a blank project. (I don't recall exactly. I may try opening it again, and send Cakewalk a bug report with the details)
Auto-Save has saved me before and I do recommend using it. I also hit Ctrl-S every time I think of it which probably saved me from even more loss.