I personally find that it is much less load to change the current screenset using keyboard shortcuts than to switch to a different screenset.
I can hit Shift+D and not experience a dropout where hitting 2 to get to the identical layout shift+D would have brought me may cause a drop out.
Now, if I can afford to stop playback, then screensets are great.
Or if I can afford to push up buffer samples to 2048 or something, screensets never cause me dropouts.
But I rarely switch between screensets while tracking.
I have not experienced System Crashes while using screensets, but I have experienced dropouts.