I've done other projects with GPO and not had this problem. It seems to occur only in one project so far. I'm going to open a new project and copy the midi track from the problem project and see if I can use GPO in the new project to accomplish the work. If that works I'll copy the final audio track to the project that keeps crashing and hope that it doesn't crash. I haven't done much with the project since deleting GPO, so I'm not completely sure the issue is gone.
I tried going back to X2 with this project to see if I could finish the work there, but I encountered the same crashes. I've spent time on the phone with Cakewalk support to see if the cause could be isolated. We were not able to determine the cause, so a case file was opened to examine the data to see why this might be happening.
I should add that I haven't tried working on other projects that have GPO and other plugs since X2, so I can't say with certainty that the problem won't occur in these projects in X3. Seeing that the OP seems to have the same problem is reason to think that there *may* be a bug.
I'm using a Sweetwater Creation Station 400 that is about a year old (upgraded to 16GB of RAM) with a Focusrite Saffire Pro 40 & Windows 7.