I use my UFX via USB and have had no problems whatsoever even with high channel counts at low latency. RME drivers are the best in the biz. I record orchestras on location and the stability of the interface with the added USB port in front for a backup is a dream come true. I have used Mackie, ECHO, Motu, Steinberg, E-MU, Tascam, M-Audio, and Avid (Digi) interfaces and the UFX is definitely the top of the litter. Don't think twice about it, get one if you can.