I have an Apogee Big Ben providing clock to every digital device, it's rock solid.
The routing is not that complex I just do everything with an external mixer, not within Sonar like a lot of you.
I have 6 external computers that output 48 digital outs (8 each) into a pair of 02R96s.
I have 16 analog synths that get summed down to 8 outputs via a pair of Neve 5059s and then into the 02R96s.
I have 7 channels of ADAT audio (56 outputs) going out of the 2408s into the 02R96s.
Make sense so far? 112 channels meet and get mixed in external mixer.
Going back IN to Sonar via the 2408s I just have 1 channel of ADAT (8 inputs) so I can record in Sonar plus the stereo digital SPDIF signal which carries the final stereo mix which I record/bounce in Sonar.
Despite not being able to communicate my issue/problem, it is now "fixed" and I am very happy.