Cloning a C drive is possible and I have done it successfully. I had a C drive that was making a very bad sound but still working normally. It was only 80 Gig as well. I have two drives C and D drive. D drive being used for data.
I bought and used Acronis True Image (after extensive research on the subject) and I removed my D drive and installed a brand new 500G drive there. I then performed the clone except I did it in real time.
Not using the image. What happens in this mode is the computer reboots but does not go into Windows. It stops before going into Windows and the program runs and performs the clone bit by bit.
Then I removed the old C drive and put the cloned C drive (D) into the C position and put the D drive back. Everything worked perfectly. Except I had to only reauthorise two things. One was my Wavestation VST and the other was Studio One. For some reason they were the
only two things that new what had happened. I had to use an extra license for Studio One (you get 5) but they offered to give it back to me.
Everything else worked as normal and was none the wiser. You need to do something similar. You are running out of space and I was too and the thought of rebuilding my C drive was just too much. It would have taken a week. This only took an hour or so.
You have got nothing to loose by doing this because your C drive is still OK and could be put back in if it did not work for any reason.