jeebustrain
I kinda wish that was the case on my Focusrite Saffire Pro40 - the Mixer app actually locks all settings related to drivers/buffers/latency when ASIO is in use. I need to have any ASIO aware application closed in order to change settings. Not a big deal, but it's a minor annoyance on longer project sessions, when I'm tweaking latencies for softsynths and am going back and forth between different settings.
I like that feature and I can see why it is implemented. Many apps that use ASIO will crash if you change the settings in mid flow. People would be logging calls to Focusrite otherwise asking why the Saffire is crashing the ASIO app, so this reduces their support calls.... Perfectly reasonable... I notice the ASIO apps tend to inherit what the Saffire has already set anyway.
BTW please make sure you are on the latest mix control software without the legacy firewire driver if your behaviour is different to mine.