+1 Bob is a great guy!
Now that we have you in the best driver mode and running, take a look at these preference options and see where they are set (Edit->Preferences):
Audio->Devices: You should not be seeing a list of your ASIO devices, and to optimize your system, should only check the ones you are actually using (I typically leave mine as 2in/2out and leave the remainder unchecked).
Audio->Driver Settings:
Timing Masters: Be sure the two "Timing Masters" are assigned to your MOTU. This should happen automatically when switching to ASIO mode, but I have seen a couple instances where it did not.
The "ASIO Panel" button at the bottom is where you will want to set bit-depth, sampling rate, and ASIO latency. For my interface, I have found that it does run smoother when that panel is open while using SONAR, but this is not universal so is something else to check. I would start with something relatively "tame" and choose 24 bit, 44.1kHz sampling rate, and ASIO at 128. Verify that these correspond to the values on that Preferences tab (the only one you can probably adjust in ASIO mode is Sampling rate (the Audio Driver bit depth and Buffer Size slider will probably be greyed out). Note - some ASIO panels "lock" to SONAR, so you may need to do adjustments with this ASIO panel open, but SONAR closed, and then open SONAR and verify that the Audio->Driver Settings do match.
Sync and Caching (Advanced mode at the bottom): The I/O Buffer sizes near the bottom you will want to check and do this in tandem with the ASIO latency mentioned above (start with 512 for both of these)....
Increasing ASIO latency will reduce pops/crackles, but increase latency. Start at 128 for ASIO, and 512 for both I/O buffers. If you are still getting pops crackles, you may have to adjust to find the sweet spot:
- Try adjusting I/O buffers (Advanced Mode: Preferences->Audio->Synch and Caching) both up and down until happy. 256 jumps should do.
- If after trying all sizes up to 1024 you still have issues with playback, increase the ASIO latency to the next setting (Preferences->Audio->Driver Settings->ASIO Panel...) and go back to step 1 and repeat the I/O buffer adjustment.
- Repeat as necessary until you find the "magic" combination for your setup.
Edit: Bob posted before me, I am glad our recommendations match!