Are you running old versions of these synths? I know Pentagon is a DXI plugin, and I thought they redid these as 64-bit plugs.
I did look, and on my system, Pentagon lives in a sub-folder for 64-bit programs, in the following path:
C:\Program Files\Cakewalk\Shared DXi\Pentagon I
So, did you install these plugins when you upgraded to X3? I do not know when they made the change to x64 for Pentagon, but if you are running some old version of it, perhaps you want to do a custom x64 install for only those synths, to make sure you have any updates to them.
When I click on the RGC Audio at the top of the Pentagon plugin UI, it shows version 1.4 - perhaps you can check yours, as mine plays just fine, after inserting an audio track, setting input to that track to the stereo output from Pentagon, and inserting a midi track and setting the output to Pentagon.
Hope that helps,
Bob Bone