I also agree that the cpu may be the suspected culpret..So..reduce the IRQ calling or polling, by reducing redundant devices first in BIOS...not in control panel...As I believe if you turn things off in control panel the drivers are still loaded up for the devices not being used, which can cause conflicts with other drivers being used.?..(perhaps even a virtual IRQ is tagged and held?)
So removal of those devices by turning off the devices IN THE BIOS, removes them drivers from the driver list in WIN and they do not show up in control panel at all....(windows will poll the list continually to see if any changes occur.)...just another processes one does not want happening when recording or doing playback in DAWs.
Next step is to turn off apps and background services which are not necessary to run while doing recording or playback of audio.
That task is system specific...also remove things from the start up /msconfig, that boot up with win that are not necessary.
Making your system
exclusive for the task at hand, may calm down the interference.