This still stinks of drivers IMHO...
When you ran X3C did you have
64 bit double precision engine disabled in preferences? If not that is worth a try. In fact try it will your current version. Frankly I would be running at least X3B and I'm still encouraging to run X3C as I'm pretty sure this isn't the cause of your issue... but this is your judgement call.
I know you explained that you had the latest drivers, but to be specific you are definitely running Delta Audiophone drivers ver 6.0.8?
http://www.m-audio.com/index.php?do=support&tab=driver&serie_ID=1&PID=3cd08875f11d39ab23a3a59667b367e8&OS=x107 THINGS TO TRY....
Please run
chkdsk on all your hard drives.
When was the last time you ran Windows update? If not recently then please do it several times, please install the optional fixes to do with performance and stability as well.
Please run
driver boost (pay careful attention to the instructions). At the very least it will give you a report of what drivers are out of date (find this out for yourself).
For fun, run a
defrag.
After you've done all this, and if the issue persists, please check your
Windows event viewer for errors, please paste any errors here.
Also at any stage have you every been asked to rename AUD.INI or run Sonar in safe mode? If not that is next on the list.
Hope this helps... BTW it seems the only person you can trust here to fix your issue right now is yourself... Thanks..