I always freeze rather than turn off synths (don't know if that actually makes any difference, it's just what I do).
The only issue that seems to occur with that particular synth is that the sound preset seems to always revert to it's default when unfrozen, so I have to remember to re-select the sound it should be before re-freezing. I've never used it that much so always assumed that it was something I was doing wrong as I've never seen it happen with any other synth other than the odd demo, which are crippled deliberately.
Stating the obvious maybe, but sometimes we all overlook the obvious, does this also happen in your back up copy?