Back when CW first came up with the 64bit internal engine, there was much talk/discussion/down right arguing about the benefits/lack of 64bit internally. And at the time I read more about the subject than I ever thought I needed. But it was very interesting.
The reason I am reluctant to explain in detail is because of my limited knowledge. Someone with better explaining skills than I have will jump in. Those guys who know the deal are really eager to teach others.
And when they see someone stumbling to explain, they usually come in and clear things up. :)