I have... but I do it with dedicated hardware. I tried out the Dirac software and found that the room correction was pretty amazing, but the driver was crap and getting it to work with anything was a pain. So I went the hardware route. I have an Emotiva XMC-1 that is the DAC/preamp/correction/router for my system and I loves it. I am 100% sold on Dirac, it is far and away the best room correction I've ever used. I wanted the XMC-1 because I use home theater speakers, and because I wanted a surround solution (I have a 7.1 setup).
Other hardware options that are cheaper, but still pricey, can be had from MiniDSP. They have a line of 2-channel Dirac Live units that are $800 each (price includes calibration mic) that are quite nice. You have the option of analogue or digital on the input and output side. They also have a $1000 surround unit, but it is analogue I/O only. The digital one (DDRC-22D) could be placed right in line between a soundcard and DAC, or looped out an AES output and back in to the soundcard if you wanted to use the DACs you have and add Dirac.
If you want to go the software route, contact them and see if they can offer help. They aren't wonderful, but aren't useless. Also you can ask them about trying out their VST plugin. They have one, it is just in private beta at the moment. However they will usually let you try it, if you ask.