Did you run windows update several times (there have been several USB fixes for instance)?
I also suggest you install the optional performance fixes in windows update.
You said you disabled onboard sound - in the BIOS?
Disable intel speedstep in the BIOS just for fun I suggest anyway.
See if you can pull out all USB devices other than you keyboard and mouse (heck maybe even pull out the keyboard and mouse when playing and put them back in). See if you can hear Angus screeching his head off.
Any later drivers here to try (what version of mix control are you running?) NB stick to ASIO mode.
http://beta.focusrite.com/releases/scarlett_mixcontrol/
Anything at all in in the
event viewer?
Maybe a screenshot of mix control would be nice.
Last thing to try, driver Booster should have updated your motherboard chipset drivers (I hope), but I'm wondering if there is a BIOS update for your motherboard?
Focusrite support are brilliant BTW, might be worth sending an email so you can get on their call logging. You might want to point them to this thread, maybe even do a non indexed YouTube vid (you don't have to, just an idea). I notice they've even be posting here but you will probably need to log an issue with them once all this is exhausted.
Any other ideas Johnny (don't worry we are friends now, apols for coming down so hard)..
Cheers...