Amplitube and S-Gear have become my staples. I haven't touched TH2 in a year.

The big problem with AmpliTube is that it does not include everything... it is a base program that you buy modules for. A lot of the stock patches don't have the heads/cabinets/effects needed to make the sound.  This personally drive me INSANE. Yes you can try out new modules for a week or whatever, but when I want a sound, I want it NOW and not for more money.
 
I've actually come around on the program itself, but their business model eats it. Scuffham and GR5 have what they have.
 
 

If you are going for the overloud guitar bundle you might as well go for the complete overloud bundle. Best investment so far for me plugin wise.