I just took a look at that Audiophile interface. Is that your main interface? Did Rain computers install it/recommend it? Is it a legacy PCI interface (which it seems to be) or is it PCIe?
The reason I ask this is because if your PCI slot is "bridged" which is the case with many new motherboards this could be causing your problems. That is why I had to buy my Focusrite. Bridged screws with the datastream somehow. What you want, and what used to be the standard was "native" PCI support which I think means it has it's own chipset whereas bridged sends it off to be dealt with by the PCIe chipset or some such nonsense. I'm not a computer tech but I think that's the story.
Also I've seen quite a few people have issues with M-Audio interfaces, particularly the PCI ones.
As soon as I bought my Focusrite USB 18i6 interface Sonar started working a whole heck of a lot better. If at all possible I'd suggest you borrow or rent a different interface that does NOT use the PCI slot (USB 2.0 is fine for audio).
Other than that, and I'm sure it has already been mentioned but I haven't checked all the new posts here, I'd get a hold of M-Audio or check their site to see if you have the correct/most up to date drivers or google the interface to see if anyone else is having similar problems.
If you've already been through this my apologies but it's worth mentioning. I just hadn't checked out your interface until just now otherwise I would have said something sooner. Cheers.