I basically think all amp sims sound awful - until you tweak them properly, and then they sound great. The TH2 is no exception. I've often talked about using a parametric at an amp sim's output to notch out "annoying frequencies," but Sonar has another particularly useful option.
With the ProChannel pre-FX bin and TH2 inserted in the FX bin, engage the ProChannel EQ's low pass filter and set the slope to 48dB/octave (steepest possible). Then, lower the frequency to where the TH2 sounds smooth, and the harshness is gone. This will often be in the 5kHz range, but as always, it's a matter of taste.
This is the same basic principle as rolling back a guitar's tone control for a smoother distortion sound, but is more effective at preventing high frequencies (which don't distort all that elegantly) from entering the TH2.
If the sound isn't bright enough for you, then add an EQ after the TH2 (Nomad, Sonitus, whatever) and start boosting at around 4kHz (again, according to taste). The sound will still be sweeter because you'll be boosting a smoother, more organic sound instead of one that's harsh and has too many harmonics.
Remember that in the real world of guitar amps, most cabinets have very little energy above 5kHz or so. The cabinet acts as a low-pass filter that removes a lot of the harmonics generated by a tube preamp/amp section. Although you could always just filter out the highs after an amp sim to replicate this effect, preventing the highs from entering an amp sim in the first place is a more effective way of dealing with the digital world.
For this reason, another useful option that can either complement or replace using the ProChannel lowpass filter is using a de-esser in front of the amp sim to make sure highs don't go into the sim when the guitar is generating high levels. I use the VC-64 for this and place it in the FX bin, before the amp sim.