I just did a batch re-save for Kirk Hunter Concert Strings this morning. I'd done that on the old DAW but couldn't remember how much it helped, only that it did. So this time I did a before-and-after benchmark.
I have a large multi consisting of 6 string sections (1st and 2nd violins, 1st and 2nd violas, cellos and basses) that I loaded into standalone Kontakt. Prior to the re-save, it took about 5 minutes to fully load (meaning when the Memory usage display stops incrementing). I then rebooted the machine to eliminate the effects of caching and loaded the nkm again. This time it took 3 minutes to fully load. Still a monster, but that's a significant improvement.
(Note that you have to expand each instrument's UI in order to know when loading actually completes. The hourglass goes away and UI controls come to life after only 6 seconds, but with background loading enabled, samples are still being read.)