Wow! I've been having intermittent spikes and dropouts on my new box so I went through some of the recommendations I found on this thread and everything works really well now. The dropouts are now completely gone even with the lowest latency settings. I was even able to drop my midi buffer to 32ms with no cut outs.
I've got a quad core i7-4770K with 32 gb.
The following worked wonders:
1. Turned off powerstep, C3 states, and Turbo boost
2. Turned off the page file.
Bugs squished, thanks to all for the info!
Just wow!