+11 on so many points. I developed problems in 1995 when code editing took a quantum leap upward at a new job (supercomputing center, go figure

). Unbearable pain in my right index finger, shooting all the way up my right arm. What helped it:
Switching to left-hand mousing.
Physical therapy (and chiropractic therapy too).
Using as many keyboard shortcuts and macros as humanly possible.
Using a trackball, if possible. (
This Logitech that Xavier linked to before. My only wish... that it included a real scroll wheel. The Logi driver can "fake" a scroll function (mode-shift on the trackball) but it's not quite the same for my taste. Otherwise, it's perfect.
It's weird... by now, I've been mousing with the left hand longer than I ever moused with the right hand. (Longer in years, and in hours by far.) I was thinking, all else being equal, that I would have started to see problems on my left hand long ago. But knock on wood, there have been no problems whatsoever. On the other hand (ouch, very bad pun), when I still sometimes forget and mouse with my right hand, say, picking up some work on someone else's workstation, the pain comes back in short order to remind me.
I wondered if it was just good habits, and it might be, but reading here, it may also be due to the posture improvement from the different centering you get with the left-hand position.
Using left-handed mousing with a right-handed mouse... is that sort of like playing upside-down left-handed guitar?