Well, since you need the firewire port, you have to make sure it isn't sharing the same bus as the USB port that your mouse is plugged in to. If the firewire port is on a separate PCIe card, try moving it to a different slot. Otherwise, try moving the mouse to a different USB port, preferably one that is on a different bus.
If you can't resolve the issue by moving things around, and your firewire port is on the motherboard, I would suggest that you purchase a PCIe firewire card and disable the port on the motherboard.
Regards,
Dan