I had to roll back to x3b as well (using system restore).
In x3c some of my projects would just lock up (had to close them using task manager), some worked normally, but most would play some tracks but not others.
The tracks that would not play any audio would give a loud pop when I would first hit play and the meter for that track would show 9 db in the red. If I deleted all pluggins and prochannel effects sometimes it would work for a while.
I tried tracking it down to specific plugins, but it was too random (besides a couple voxengo plugins, Kontakt, and Guitar Rig, I'm using mostly Effects from Sonar).
This is on Windows 8.1 AMD system with a MR816x using AISO
Buffer settings, or switching to WDM made no difference.