PerfectSpace adds a fair amount of latency and CPU overhead. Follow scook's suggestion of using a lightweight reverb as a placeholder until you're done tracking, then replace it with PerfectSpace and increase your interface buffers in preparation for the final mix. I've never had any issues with PS, despite my DAW being old and relatively underpowered by current standards.
Latency is somewhat adjustable in PerfectSpace. You can lower its internal buffer size to reduce latency, but more often you'll want to raise the buffer to ease the load on your CPU and reduce the likelihood of glitches during playback. CW suggests setting it to 1/4 the size of your interface buffers, but I leave PS at 1024 but mix with 2048 on my interface and don't have any problems. I'd guess as long as the PS buffers are smaller than the interface buffers you're OK.
But the most important principle when it comes to PerfectSpace is that the quality of the reverb sound depends mostly on the impulse response file it's using. It's worth the effort to look around online for some alternate IR files, as there are many excellent ones available for free.