spacey
What if I have a great sounding 335 and a kid with little short arms and little hands that can't even fret a note on it? Are you still going to focus on tone as if it's the only thing that matters? It's not limited to tone by those that know there are many things that make a great guitar.
And what makes a guitar great for one person can make it the opposite for someone else. As you say, a key thing being fit and ergonomics. I have the same "problem" as Johnny Winter - I prefer single-coil sound and response for blues playing, but find Fender scale lengths almost a stretch too far at times. His answer to that was Firebirds, mine is to work round it and maybe just do things a bit differently. There are guitars I simply wouldn't even attempt to play some things on and I found out 40 years ago that formal classical guitar technique is well outside my comfort zone.
As for pricing, the biggest gains in quality for money spent generally come in near the lowest end of the price range. The difference between a basic Squire jazz bass and the Made in Mexico equivalent is noticable. The difference between a MIM and US standard is less noticable and the MIM, depending on model, may well be closer in many ways to the "vintage" Fender production methods and materials quality than the price difference might suggest.
Yes, I do think you pay a bit extra for the "Made in USA" tag. Maybe ironically, if you want a Tele or bass made pretty much in the "old way" with vintage oitput pickups etc. most of the US range isn't that. As for Gibson, while their guitars generally involve more labour than Fender, all that shaping, and the lacquer taking quite a lot of time and polishing to get right, much of their range is knowingly priced to exclude most customers - I've seen an interview with Henry J where he pretty much said so.
I think that once you get to the sort of prices Fender, PRS or Gibson attach to their most expensive products you're really looking at something aimed at least as much at wealthy collectors rather than musicians. Fender's relic replicas of some famous person's Strat being one example.
What's often forgotten is that the famous guitarist probably pulled instruments off the rack in the shop until they found one they liked, and the same goes with effects and amps. There was nothing "special" about any of it when it was made, the mystique came along later because the owner was or became famous. And just because e.g. Jeff Back's Strats suit him doesn't mean a replica of one of them will be the best Strat for you because you're not him.