Having downloaded and launching X3 without my ASIO interface turned on, I'm afraid my wave profiles weren't correctly read to properly work with my interface (in my case, my Roland Juno Gi)
How do I manually rerun the wave profiler to correctly read and make the necessary settings for my interface?
I have tried to make changes in the Driver settings under Preferences on the tab under Mixing Latency, however after selecting ASIO, it won't allow me to make any other selections now.
Also, can't change Audio Driver Bit Depth.

Don't worry about the wave profiler if you are running ASIO. It is not for the ASIO driver mode. When running using an interface using an ASIO driver, the manufacturer of the driver supplies a client to configure the driver. The configuration is only read by SONAR. If you want to alter the bit depth for your projects go to Preferences > File > Audio Data and change "Record Bit Depth".

Thank You Scook! Everything seems to be working correctly, I just wasn't sure if I was gonna get the best performance that I should!
When I first launched after my download I didn't have my interface on and it read my computers internal sound card profiles, I noticed it working through the headphone out jack where it hadn't worked there before with X2, and I also noticed that it had shown up listed in the Preferences Audio Devices tab! I'm not very savvy as to how all this stuff communicates with each other, but I'm gettin the hang of it slowly but surely!