Sorry, Grem. I didn't mean to imply you had an underpowered system. Your CPU is the same as mine and I've got 16GB RAM as opposed to 8 is more than enough. TH2 is supposed to be a low resource effect (compared to stuff like GR). A poor graphics card or set up MAY be the culprit but I'm running a $20 Gigabyte special (but it does have a GB of video RAM which is supposedly a good thing) and do not get the audio problems you are but still might be worth looking to see if maybe there is a driver update for your vid card.
However you said it... try it out on a clean project. I'm just guessing but it sounds like the project might have gotten a little corrupted during its travels through the multiple Sonar versions. 256 though is kind of low IMO if you are just mixing/tweaking and experience audio glitches... even if the CPU/RAM meters aren't maxing out. I don't think I've managed to get my CPU pushing 20% on the first core yet except when I was being a real jerk to my system.
It's probably a combination of little issues with the project that are adding up to annoyances. When I was still on X1 I had the exact same problem with adjust pretty much ANY parameters during playback (which is extremely annoying while trying to mix) and turning up my buffers pretty much always helped. Those problems went away with X2.
Another thing... what speed are your drives spinning at? 7200RPM is recommended. 10,000 is better... SSD is betterer (at least for the program drive). Cheers.