I have a fast computer and an RME audio interface.
One of the problems that is very difficult to avoid is that the plug ins (like Waves VSTs) have built in latency and will cause your DAW to have latency no matter how fast your hardware system is. For instance if you have a Waves L3 in the signal chain the latency will increase by more than 3000 cycles.
One solution is to turn off your plug ins while tracking.
Another solution is to run your live synth in another VST shell with no plugs, so in essence you have a stand alone synth. Or load your synth in a separate computer.
I find this issue very annoying.
I would love to try an 18 core computer with fast everything, tell us how it works out.