Something I discovered, depending on your audio system...
Even though this sounds counter intuitive, there is a setting in the .ini file for MAX THREADS... if you are getting stuttering at lower latencies, it actually helps to set this at 5 or 6 to allow your PC audio drivers to get enough CPU power.
I have an APOLLO running in TB and this really helped my system... I stumbled upon this trying to get the audio glitches out of the signal chain and I have mine set at 6 even though I have eight threads available (SONAR gets 6, the OS gets the other 2).
This is in addition to the other suggested settings for multiple core CPUs above, not instead of.
Hope this helps someone else out,
Jim