Starise
I'm wondering if computer I.D. issues could be a factor in gradual replacement, especially with motherboards and main OS hard drives.  I might add memory later on or an extra hard drive. I don't think this flags win 10. If new OS, then it doesn't matter I suppose.
 
In the old days , you could simply replace the mobo and keep the main HDD and usually there would be no issues. With newer OS I'm not so sure.

I have heard that it is now possible with Windows 10 to put in a completely different mobo and CPU and still boot up from the same disk.  No reinstall required.  Something to do with a new hardware abstraction model in Windows 10.
 
Not entirely sure how this affects Windows activation.  May have to call them to explain.
 
As far as application license managers go, they probably each have their own thresholds.  If in doubt on any specific ones, probably best to de-authorize them first before swapping hardware, and then re-authorize after.

The license affects how many changes can be made and registered. Odm and oem licenses are normally tiedtotheir the computer out a set up on.

In Windows 10 (Version 1607 or later), you can link your Microsoft account to the Windows 10 digital license on your device. This can help you reactivate Windows using the Activation troubleshooter if you make a significant hardware change later, such as replacing the motherboard.
 
https://support.microsoft.com/en-us/help/20530/windows-10-reactivating-after-hardware-change
 

So it seems it would really pay to link to an MS account if changing major hardware...and even then I would be leary, but that's me. Great info guys. Thanks.

Starise
So it seems it would really pay to link to an MS account if changing major hardware...and even then I would be leary, but that's me. Great info guys. Thanks.

 
In reading the article, it seems that you can still link your digital license to your account even if it is not a connected account. I have not tried it yet, so YMMV.
 
I run a local account only, but I would consider doing this temporarily if I was planning a hardware upgrade.  I would switch back to local only after the upgrade if the link was persistent.
 
How to Delete Your Microsoft Account & Create a Local Windows 10 Login
http://www.makeuseof.com/...ocal-windows-10-login/
 
How to remove a device from your Microsoft account
https://www.howtogeek.com...our-microsoft-account/