I got to the bottom of this problem. I gave up trying to install the UAD 2 quad. Their drivers would recognise the hardware on both of my computers. However Lance was able to get one working on a different machine and we could repro it.
I finally found the problem by inspecting our UAD specific code. It has to do with a custom UAD API that we use for optimizing chaining UAD plugins side by side. This API doesn't handle VST3 plugins and therefore causes the crash.
I will test my fix tomorrow.