I had a similar issue, the very first project I opened caused X3 to crash. It opened fine in X2. I used safe mode to open it, not allowing any suspect plugs to load and it opened OK. One of the things I did not allow was old Melodyne studio plugs.
Could the fact that I had old Melodyne instances in the project cause X3 to crash? X3 seems to have integrated my copy of Melodyne studio seamlessly, and it's running fine in the project now.
I did send the crash dump files to CW, so hopefully they will be able to figure out what's going on.
John