Yes, track interleave does govern the plug-in setup. If the plug-in is inserted when the track interleave is set to stereo, the plug-in will present input selections. If the plug-in is inserted when the track interleave is set to mono, the plug-in input selections are greyed out. Subsequently changing the track interleave does not affect the plug-in input selector.
I just dropped the plug-in in the track so the interleave was set to the default, stereo.