CRX... what sound card are you using and what driver mode?
Factory cards can do this. It tends to show up more when working with MIDI based stuff using softsynths. Factory cards can generally handle the audio stuff pretty well.... aka: using it as a tape recorder..... but the load placed on the sound card chips to process the softsynths in real time is often too much.
If this is the problem, a dedicated USB interface running ASIO will generally solve the issue.....
Check your midi settings..... latency, and buffers first though..... you can generally adjust them a bit to get improved performance to a certain point. The best solution though is a dedicated interface.