I am a M-audio audiophile PCI 2496 soundcard user with Sonar X2 PE with windows 7. No problem here. Has been using that since Sonar 8.5. I have heard that M-audio has been very slow in updating their driver. So it is important that before you purchase any hardware you must make sure that the proper driver for your operating system is available for download from their website.
One minor annoyance was that the use of a particular software (I forget which one) tends to make the m-audio driver's control panel disappear. It was latter resolved by visiting M-audio's support website and they mention something about going through MSconfig setting. I had never experience that again when and updated driver was installed.
Other than that I am very have happy with my M-audio soundcard. It's advantage is that it is very stable, quiet, and fast. It's speed and low latency (128ms) allows me to enjoy playing softsynths with ease. That is my experience. My other interface is Cakewalk's UA25EX.