The obvious questions first :
Are you running it using a mains power supply as against USB power supply (or batteries) ? Mains would be the way to go, using a transformer/wallwart
Have you tried plugging it into a different USB port ? This will force a driver re-installation.
Have you updated the SD50 drivers, if there are any ? If there are updated drivers, delete the older ones first then install the newer ones BEFORE plugging in the SD50 (or Line 6)
I have an SD20 and its a cantackerous bar-steward at the best of times, but the method below worked for me and for the last 12 months or so, no problems.
Try deleting the drivers, deleting the USB port (or ports if you're felling brave) in the Device Manager then rebooting and letting Windows re-install a fresh set of drivers (before you re-plug in the SD50 or Line 6). But (yes, there's always a but, you may have to re-install all your USB drivers by this method, but its worth a try and worked for me.
Good luck to both of you,
Cheers,
Jerry