So, for a long time I switch screen-sets while not monitoring because I cause drop-outs when I do.
 
I just realized that when I max out my interface latency setting to 2048, I can switch screen-sets all day without a drop-out.
 
I'm only posting to share the revelation in case anyone else was slow to the party.
 
I often wondered why I could D to raise and lower the dock during playback but I couldn't switch screen-sets. This will be a big help and maybe I'll actually start taking advantage of screen-sets. Currently, I'm pretty fast on I and D and B etc, but screen-sets do so much more, like enabling layouts of all your plug-ins so that you can flip to watch.
 
Now that I have a desktop instead of a laptop, I'm back to one monitor which is turning out to be a challenge all over again.