You should be able to do everything with take lanes that you did with layers. The only difference is you will encounter more bugs with take lanes*.
One thing to definitely use on multi-mic tracks: Clip Groups! In Preferences, Sonar can be set to automatically group clips across tracks recorded in the same take. Or after the fact, select multiple clips, right-click and "create selection group" (it no longer says "clip group" despite the X2 documentation). Once grouped, selecting a clip selects all clips in its group, and you can edit as a group.
It would be great if we could freely edit a group without having to explicitly select a clip first. So many times I think the group is selected, yet I'm only editing a single clip (then must undo everything and re-do as the group). Anyways, be sure to always select a clip before trying to edit its group.
* Some issues with take lanes:
- Moving clips between lanes or tracks is like Plinko: you don't know where it's gonna end up until you let it go.
- Clip automation becomes unselectable. You may have to collapse all lanes and re-expand to select a clip envelope.
- Unexpected things occur sometimes when you delete a lane. Sometimes it deletes clips from other lanes!
- Can't recall off-hand what other take lane bugs are out there, but be careful to verify before locking in edits.