Hi,
I am going to add my two cents in here. If your running a Dell computer STAY AWAY FROM FOCUSRITE !!!!!!!
It IS great equipment, but the firewire controller that Dell uses is incompatible with thier products. I had a Sapphire Pro40 and was a beautiful unit, but would never work with ANY of my Dell computers. Works great with my custom tower though.
If your running Vista or above then I would recommend the Audiobox series of USB connected devices. The latency is almost non-existant, and the sound is great. I use an 1818vsl as my main mobile interface, and have no complaints (except maybe that the VU meter does not go above 0db, but running full digital this is not a problem).
Cheers,
TheBadger