I boot my work laptop to
Ubuntu Studio installed on a USB Drive to play with audio when I'm not at home (or surf the web, watch Netflix movies or whatever you might need a computer for).
I have not tried to get Sonar working on Ubuntu Studio. I do use
Ardour as my Daw on Linux. I use my
RME UCX in 'Class Compliant Mode' which means that I don't need a driver for it. Ardour just recognizes the inputs. I have not succeeded in getting
RME Total Mix to work on Linux but they are about to come out with a version of it that works on the IPad to control the UCX when it is operating in Class Compliant Mode. While it is possible to adjust input levels in the UCX with the single rotary nob on the front of the device, you can't do many of the cool routing things possible when using Total Mix.
When I asked on the RME Forum I was told that it would not work with Linux.
This site has information about some interfaces that work well on Linux. My RME UCX interface isn't listed because in Class Compliant Mode, it doesn't actually need a driver at all. I have never used my M-Audio device with Linux but it looks like it's possible to get it wired up.
I did try using WINE to get Total Mix or
DigiCheck working, but I had no luck with that, probably because they were looking for the installed RME Device before allowing me to use the software. In CC Mode, the RME Software has no way of being sure it is an RME Device.