This happened to me just yesterday on a bus in X2a.
I tried absolutely everything I could think of to try and get it to spark into life - remove module + re-add module; close + restart SONAR; I even rebooted my PC to no avail.
In the end, I had to create a brand new bus and repopulate it with the VSTs and Pro-Channel modules and settings.
It's happened quite a few times since I got the Concrete Limiter, but I thought it must have been user error on my part. At least I know that others have had this happen.