It does blow up Steinberg's garbage "soft elicenser" which is no huge surprise since that is exceedingly paranoid DRM. The actual dongle still works fine, of course, but if you have a license in the "soft" part you'll lose it. So make sure you remove those first (or better yet, don't use it). I don't keep any licenses on it, but the manager whines about it being "unrecoverable".
Everything else seems happy. Melodyne, Waves, FXPansion, Overloud, Vegas, none of them seem fussed or want to reactivate. As other reported, the iLok manager didn't whine (I also don't keep any licenses on it, all of them are on the hardware).
All non-DRM'd stuff works no problem, of course.
Also instead of Classic Shell, I recommend Start 10. Much better start menu replacer. Costs more, but not a lot.
Final thing to remember is that it will drop a Windows.old directory with rollback stuff on your drive. Eats up 20+GB so once you are confident in the upgrade and don't want to roll back, you should remove it with Disk Cleanup.