Thanks CJ,
I just learned that the importance is that Gain (or Trim) is Pre FX whereas Volume is Post FX.
IOW any FX, such as compression, will vary what it is sensitive to if the Gain varies.
As I now understand, it still makes sense to use Gain Automation if it is mainly to make the original signal consistent in level (say fixing a section where the vocalist moved away from the mic for a bit, or a punch-in was at a different level), but not to control raising and lowering volume during the song for dynamics, say during a raising of volume from verse to chorus.