Summary:
A straight round trip works just fine. Send the clean guitar into the processor and record the result to a new track in Sonar. You have to pull the resulting clip back but that's not really a big deal. The only thing I think I'm noticing, is that playing the guitar into it normally doesn't seem to sound the same as sending it the prerecorded clean guitar. It could be my imagination, I'm doing some tests.
The External Insert may be useful to some because you can save a preset and theoretically, Sonar can measure the latency and automatically compensate for it. In reality, as Mike mentioned above, you would need to perform the latency measurement every time you changed a patch because a different chain of effects would take a different length of time.
The Line 6 PODxt Pro has INs and OUTs specifically for reamping so you don't have to worry about pulling physical plugs out and re-patching them, that's
really handy. You only have to change the driver mode. My Roland GP-100 doesn't have that capability so I have to do it manually.
You can adjust the sound in real time if you're using a virtual guitar like Electricity or Shreddage. You can send the output of the virtual instrument straight into the round trip, you don't need to bounce it down first. Now you can change velocity settings in the MIDI data on the fly and hear the result immediately.
1) Set the output of the virtual instrument to the input of the Guitar Processor (i.e. OUT 1 to Front Panel IN)
2) Set the output of the Guitar Processor to another input on your interface (i.e. OUT Left Mono > IN 1)
3) Set IN 1 as the source for a new track (i.e. Track 2)
4) Select the section and set it to Loop. Press Play.
Now you can hear the result of the round trip playing on Track 2. Select the MIDI clip and enter new velocity values as required in the Event Inspector toolbar. You can immediately hear the response to more or less muting (for example).
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