I was concerned about this when TH3 got updated in 2017.10. Frankly TH2 has been nothing but a headache for me with these amps. The original CA-X amps wouldn't work if TH2 full was installed, when TH2 changed sometimes the FX chains would load but without the amps so they sounded like crap, I had to come up with separate versions for Artist/Professional and Platinum but in some cases if someone upgraded to Platinum there were issues having both installed, TH3 didn't always translate TH2 properly...I've opened many projects where if TH3 was involved, the amp didn't sound like it was supposed to because the IRs that were included with TH2, and which I used in a lot of the amps, were not in TH3. I asked whether Cakewalk could just install the old IRs, but I got the impression they weren't sure how to handle it for demo versions or Home Studio or something...I'm not sure of the exact reason.
Cakewalk assured me there wouldn't be any problems with the latest update and the older amps, but I guess that's not the case. Try this: if an amp either doesn't work or sounds like crap, delete it and drag in a new one from the browser. That might help. Take a screen shot of the old amp's settings first so you can duplicate them.
I do think when the CA-X FX Chains work as they're supposed to, they're pretty cool. But I have no idea how many people have experienced them working correctly, and how many haven't.