Sampling some of the noise after and trying to invert it will not work probably because the sample you have taken is in another point of time and the waveform may not invert well at all. In fact you might just increase the noise that way.
(I have never had success with this) You really need a separate software editor to be able to work on tracks and preferably an editor with a proper noise reduction algorithm. It is the only way and probably much better then RMIX as well.
What you do is actually sample the noise on the actual track you have recorded. This becomes a noise profile. All you need is usually a small section with just noise and no guitar sound. Then you let the software perform its magic often in several passes as well. You only have to reduce noise in the quieter bits too because once a loud guitar signal kicks in it will masked anyway.
It depends on how consistent and what type of noise it is as to how effective noise reduction is. Hiss can be harder in some respects. Too much noise reduction can effect the guitar signal too. It is sometimes much better to reduce it rather than trying to eliminate it altogether.
Sometimes setting up a noise gate right at the source can be effective as well. But doing what
Robert is suggesting is still a good idea.
(capturing a noise print that is at the time of recording) Not so much for attempting to phase reverse and null
(which won't work actually) but for a noise reduction plug to be able to capture its noise profile for later treatment. The null concept may work for mains hum but not random noise such as hiss.